Codon preference reflects mistranslational constraints: a proposal
نویسندگان
چکیده
منابع مشابه
An extreme codon preference strategy: codon reassignment.
We argue that in animal mitochondria codon reassignments, such as those for AGA and AGG from arginine to serine or of AUA from isoleucine to methionine, are the result of an interplay between biased mutational forces and selective ones. In particular, there is a marked tendency for animal mitochondria to have very small genomes and to minimize their investment in components required for gene ex...
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Pigment epithelium-derived factor (PEDF) is widely known for its neurotrophic and antiangiogenic functions. Efficacy studies of PEDF in animal models are limited because of poor heterologous protein yields. Here, we redesigned the human PEDF gene to preferentially match codon frequencies of E coli without altering the amino acid sequence. Following de novo synthesis, codon optimized PEDF (coPED...
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Codons are simple primitives for describing plane curves. They thus are primarily C.:0 image-based descriptors. Yet they have the power to capture important information about the 3D world, such as making part boundaries explicit. The codon description is highly LLL redundant (useful for error-correction). This redundancy can be viewed as a constraint on the number of possible codon strings. For...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1988
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/16.9.4111